| Hardcopy Reference: |
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| Title: |
A genome-wide scan reveals candidate susceptibility loci for pig hernias in an intercross between White Duroc and Erhualian |
| Author(s): |
N. S. Ding, H. R. Mao, Y. M. Guo, J. Ren, S. J. Xiao, G. Z. Wu, H. Q. Shen, L. H. Wu, G. F. Ruan, B. Brenig and L. S. Huang |
| Publication Year: |
2009 |
| Reference: |
Journal of Animal Science 2009.87:2469-2474 |
| Country: |
China and Germany |
| Summary: |
The objective of this study was to identify susceptibility loci for umbilical and scrotal/ inguinal hernias using a genome scan in a White Druoc × Erhualian F2 intercross. Several previously reported chromosomal regions for scrotal/inguinal hernia were validated, and new evidence for linkage with this pig defect was found. Moreover, several susceptibility loci for pig umbilical hernia were detected for the first time. Further studies will be devoted to confirming the detected markers for scrotal/inguinal and umbilical hernias in outbred populations. Identification of causative mutations or closely linked markers for scrotal/inguinal and umbilical hernias could be used in marker-assisted selection schemes for removal of this genetic defect. |
| Abstract: |
Pig scrotal/inguinal and umbilical hernias are the most prevalent congenital disorders in pigs and often cause animal welfare problems and economic loss. To identify susceptibility loci for these traits, a genome-wide scan with 194 microsatellite markers covering the pig genome was performed in a White Duroc × Erhualian resource population with 23 scrotal/ inguinal F2 animals, 50 umbilical F2 animals, and their unaffected siblings. A sex-average linkage map with a
total length of 2,350.3 cM and an average marker interval of 12.84 cM was constructed. Both nonparametric genome-wide linkage (NPL) analysis and transmission disequilibrium test (TDT) were implemented to detect closely linked markers. The NPL analysis revealed 11 chromosomal regions on SSC1, 2, 3, 6, 7, 8, 10, and 11 for umbilical hernia and 5 regions on SSC2, 4, 8, 13, and 16 for scrotal/inguinal hernia, whereas the TDT test identified susceptibility loci for umbilical hernia on SSC1, 2, 4, 7, 10, 13, 14, and 15 and for scrotal/inguinal hernias on SSC2, 8, 10, and 18. The most promising loci were SWR1928 on SSC7 and SW830 on SSC10 for umbilical hernia, and SW933 on SSC8 for scrotal
hernia, which were consistently detected by both NPL and TDT. Several previously reported chromosomal regions
for scrotal/inguinal hernia were confirmed, and new evidence for linkage with this pig defect was found.
Moreover, susceptibility loci for pig umbilical hernia were detected for the first time. |
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